The 5 Step Process on How to Substitute Chemicals

Working with substitution and phasing out dangerous chemicals is a continuous task and an important one. Not everybody knows how to conduct it efficiently. Learn more about the process and start substituting today.  To be able to perform a...

Published February 6, 2020

3 minute read

Working with substitution and phasing out dangerous chemicals is a continuous task and an important one. Not everybody knows how to conduct it efficiently. Learn more about the process and start substituting today. 

To be able to perform a chemical substitution in an effective manner - especially in the absence of software for chemical management - it is helpful to learn more about the topic. By using a step by step method on how to substitute, it will become easier to begin the process of using less dangerous chemicals at your workplace. After testing this method you will learn what works best for your company and how to establish a procedure that you and your colleagues can use.  


Download our guide on the 10 Most Common Dangerous Substances


Substituting is not as easy as replacing one chemical with another and the process might not be the same in all situations. Methods that work for one business or process, might not be suitable for another business or way of using the chemical. 

One approach to use is to look at the production techniques and product design. For example, when designing a chair, one might use the process of wedging or snapping pieces together to assemble the chair, instead of using glue or screws. Often you have to try different solutions and alternatives to find the best one. Areas to consider are: hazard and exposure to the chemicals, technical performance, economic aspects, energy and resource use and waste and recycling; among others.

Download our guide How to Replace Dangerous Substances 


A process on how you can start substituting 


Below we will share 5 steps you can follow. These steps are methods based on the ECHA model “How to substitute?”

Identify the chemical you want to evaluate, substitute and/or phase out 

  • Get an overview of all the substances/chemicals at your workplace. This can be achieved by creating a chemical register and conducting an inventory of all the chemicals present on site. You can choose to do this manually or to implement digital software for chemical management. 
  • To know what substances the chemical contains and how hazardous it is, you can easily use the safety data sheet to find this information.
  • Priorities the substances to see what chemical(s) candidates for substitution. You can look at the most hazardous chemicals that might not be necessary and chemicals with substances that are, or may be, subject to regulatory actions now or in the future. 
  • You can use regulatory lists such as: 
    - SIN-list (Substitute It Now) consists of hazardous chemicals that should be removed as they are a threat to human health and the environment. 
    - List of substances subject to authorization (Annex XIV of REACH)
    - Candidate List of substances of very high concern for authorization
    - REACH Annex XVII: REACH Restricted Substance List 2019
  • Ask yourself: What is the function of the chemical that is to be replaced?

2. Identify potential alternatives

Now it is time to look for alternatives. Ask yourself: 

  • How would you have solved the problem if you didn’t have the chemical in the first place? For example, do you really need to provide your customers with a printed receipt that may contain hazardous ink developers, or would an electronic receipt
    be a suitable alternative? 

Download Guide: 22 Substances to Substitute Now


3. Assess, compare and select alternatives

  • If you need to use a chemical, what other options can you choose from? There are digital services that you can add on to a digital chemical register to find options to use and evaluate other chemicals. 
  • In what ways can humans or the environment be exposed to the alternative product or waste products during manufacture, use, disposal of waste or in recycling?
  • How does the alternative method or substance affect quality and function?

    In the substitution process, prioritize which elements you assess first and how these are detailed. When looking at different chemicals, always evaluate the risks. How hazardous the chemical is and how people and the environment will be exposed. You can use the SIN-list during this step also. Look at the lifecycle perspective both for new product designs without chemicals and the chemicals hazard compared to gas emissions, for example


4. Test, implement and improve

  • Choose what new chemical or problem-solving solution you are going to test first. Decide how the test will be performed and how long the test period should be. Look at the different costs of the different methods you will use to test the new solution. 
  • When your pilot test has been successfully launched, you can start to implement the alternative. Make sure you have a detailed plan to implement the substitution. 
  • Collect feedback from everyone who is directly affected by the substitution and make necessary improvements. Make it easier to evaluate and improve over a longer term by using a chemical management system. 

5. Inform your supply chain

  • Your customers and suppliers might need to be informed of your changes. Perhaps you also want to publicize the information on your website to gain an advantage over your competitors.
  • Keep in mind that your customers might need time to inform their customers about your changes. 



After completing the above steps and finishing the substitution, you can summarize the experience and create a standard operating procedure that can be used by yourself and your colleagues for future substitutions.


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Author Tanya

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